|Other Accession||NM_016776, NP_058056|
|Reactivity||Human, Mouse, Rat|
|Alias Symbol||AL024407, AU019902, P160, p160MBP, p67MBP|
|Other Names||Myb-binding protein 1A, Myb-binding protein of 160 kDa, Mybbp1a, P160|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Mybbp1a antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Mybbp1a antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230).|
|Cellular Location||Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1.|
|Tissue Location||Ubiquitously expressed.|
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