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TSG101 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - TSG101 antibody - middle region AI12066

    WB Suggested Anti-TSG101 Antibody Titration: 2.5μg/ml
    ELISA Titer: 1:62500
    Positive Control: NIH/3T3 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q61187
Other Accession NM_021884, NP_068684
Reactivity Human, Mouse, Rat, Rabbit, Goat, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rabbit, Pig, Goat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Additional Information
Gene ID 22088
Alias Symbol CC2, AI255943
Other Names Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, Tsg101
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-TSG101 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTSG101 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsg101
Function Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis {ECO:0000250|UniProtKB:Q99816}
Tissue Location Ubiquitous. Higher expression in brain and mammary gland. Lower expression in liver and tumoral tissues
Research Areas
Citations (0)
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References

Stefan,M.,etal.,(er)BMCGenomics6,157(2005)ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.

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$ 339.00
Cat# AI12066
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