|Other Accession||NM_006910, NP_008841|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Bovine, Dog|
|Alias Symbol||DKFZp686P0638, DKFZp761B2423, MY038, P2P-R, RBQ-1, PACT, SNAMA|
|Other Names||E3 ubiquitin-protein ligase RBBP6, 6.3.2.-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis, RBBP6, P2PR, PACT, RBQ1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-RBBP6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||RBBP6 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||P2PR, PACT, RBQ1|
|Function||E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10- dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).|
|Cellular Location||Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome|
|Tissue Location||Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer|
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