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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RNF139 antibody - N-terminal region   

RNF139 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - RNF139 antibody - N-terminal region AI12216

    WB Suggested Anti-RNF139 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:312500
    Positive Control: MCF7 cell lysate
    RNF139 is supported by BioGPS gene expression data to be expressed in MCF7
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WU17
Other Accession NM_007218, NP_009149
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 76kDa
Additional Information
Gene ID 11236
Alias Symbol HRCA1, MGC31961, RCA1, TRC8
Other Names E3 ubiquitin-protein ligase RNF139, 6.3.2.-, RING finger protein 139, Translocation in renal carcinoma on chromosome 8 protein, RNF139 (HGNC:17023)
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-RNF139 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsRNF139 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF139 (HGNC:17023)
Function E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney.
Research Areas
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$ 293.00
Cat# AI12216
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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