|Other Accession||NM_012158, NP_036290|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Sheep, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||FBL3, FBL3A, FBXL3A|
|Other Names||F-box/LRR-repeat protein 3, F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3A, FBXL3, FBL3A, FBXL3A|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-FBXL3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FBXL3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855).|
|Cellular Location||Nucleus. Cytoplasm. Note=Predominantly nuclear|
|Tissue Location||Widely expressed.|
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