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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   HERC5 antibody - N-terminal region   

HERC5 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - HERC5 antibody - N-terminal region AI12234

    WB Suggested Anti-HERC5 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:62500
    Positive Control: HT1080 cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UII4
Other Accession NM_016323, NP_057407
Reactivity Human, Bovine, Dog
Predicted Human, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 117kDa
Additional Information
Gene ID 51191
Alias Symbol CEB1, CEBP1
Other Names E3 ISG15--protein ligase HERC5, 6.3.2.-, Cyclin-E-binding protein 1, HECT domain and RCC1-like domain-containing protein 5, HERC5, CEB1, CEBP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-HERC5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsHERC5 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HERC5
Synonyms CEB1, CEBP1
Function Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant- negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.
Cellular Location Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit
Tissue Location Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels
Research Areas
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$ 293.00
Cat# AI12234
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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