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Trim11 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q99PQ2 |
| Other Accession | NM_053168, NP_444398 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Rat, Rabbit, Pig, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Gene ID | 94091 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase TRIM11, 6.3.2.-, Tripartite motif-containing protein 11, Trim11 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Trim11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Trim11 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Trim11 |
|---|---|
| Function | E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX (PubMed:18628401). Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis (PubMed:18628401). May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences (PubMed:18628401). May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (PubMed:12670303). Mediates MED15 ubiquitination leading to proteasomal degradation (By similarity). May contribute to the innate restriction of retroviruses (PubMed:18248090). Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression (PubMed:18248090). Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain (PubMed:18248090). May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle (PubMed:18248090). Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2 (By similarity). Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=In the nucleus, colocalizes with PAX6. |
| Tissue Location | Expressed in embryonic central nervous system (CNS), kidney, thymus and gut. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12273
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