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Slc26a2 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q62273 |
| Other Accession | NM_007885, NP_031911 |
| Reactivity | Human, Mouse, Rat, Rabbit, Sheep, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Mouse, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81kDa |
| Gene ID | 13521 |
|---|---|
| Alias Symbol | Dtd, ST-OB |
| Other Names | Sulfate transporter, Diastrophic dysplasia protein homolog, ST-OB, Solute carrier family 26 member 2, Slc26a2, Dtd, Dtdst |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Slc26a2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Slc26a2 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Slc26a2 |
|---|---|
| Synonyms | Dtd, Dtdst |
| Function | Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:24302720). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (PubMed:20219950, PubMed:22190686, PubMed:24302720). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (PubMed:22190686). Essential for chondrocyte proliferation, differentiation and cell size expansion (PubMed:24302720). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P50443}; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O70531}; Multi-pass membrane protein |
| Tissue Location | Distributed mainly in the thymus, testis and osteoblastic cells (PubMed:9370300). Highly expressed in the bone, cartilage, kidney and colon (PubMed:24302720) |
Citations (0)
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Application Protocols
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$ 389.00
Cat# AI12316
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