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Slc22a3 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9WTW5 |
| Other Accession | NM_011395, NP_035525 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine, Dog |
| Predicted | Human, Mouse, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Gene ID | 20519 |
|---|---|
| Alias Symbol | EMT, Oct3, Orct3, Slca22a3 |
| Other Names | Solute carrier family 22 member 3, Organic cation transporter 3, Slc22a3, Oct3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Slc22a3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Slc22a3 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Slc22a3 {ECO:0000312|MGI:MGI:1333817} |
|---|---|
| Function | Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10966924, PubMed:18513366). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)- independent, bidirectional uniporter (By similarity). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, homovanillic acid, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:18513366, PubMed:19416912). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (By similarity). Also transports guanidine (PubMed:10966924). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (PubMed:27659446). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein. Mitochondrion membrane Endomembrane system. Nucleus membrane. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes |
| Tissue Location | Highly expressed in placenta (PubMed:10966924, PubMed:9933568). Highly expressed in kidney cortex (PubMed:10966924) In kidney, expressed specifically in the proximal and distal convoluted tubules and within Bowman capsule (PubMed:10966924). Expressed in brain, particularly in dopaminergic neurons of the substantia nigra compacta, non-aminergic neurons of the ventral tegmental area, substantia nigra reticulata, locus coeruleus, hippocampus and cortex (PubMed:18513366). In brain, also detected in astrocytes in the substantia nigra reticulata, several hypothalamic nuclei and nigrostriatal region (PubMed:18513366, PubMed:19416912). Expressed in neurons and glial cells of amygdala (PubMed:27659446) |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI12364
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