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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SLC26A5 antibody - middle region   

SLC26A5 antibody - middle region

Rabbit Polyclonal Antibody

  • IHC - SLC26A5 antibody - middle region AI12387
    Human Lung
  • WB - SLC26A5 antibody - middle region AI12387

    WB Suggested Antibody Titration: 2.5 μg/ml
    Positive Control: HepG2
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58743
Other Accession NM_198999, NP_945350
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Additional Information
Gene ID 375611
Alias Symbol DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES
Other Names Prestin, Solute carrier family 26 member 5, SLC26A5, PRES
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-SLC26A5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSLC26A5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC26A5
Synonyms PRES
Function Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Lateral wall of outer hair cells.
Research Areas
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$ 232.00
Cat# AI12387
(40 western blots)
Availability: 2-3 days
Bulk Size
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