|Other Accession||NM_010149, NP_034279|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Erythropoietin receptor, EPO-R, Epor|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Epor antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Epor antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.|
|Cellular Location||Isoform EPOR-F: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells|
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