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Atp4b antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P18598 |
| Other Accession | NM_012510, NP_036642 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34kDa |
| Gene ID | 24217 |
|---|---|
| Alias Symbol | S76401S1, Atp4b |
| Other Names | Potassium-transporting ATPase subunit beta, Gastric H(+)/K(+) ATPase subunit beta, Proton pump beta chain, Atp4b |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Atp4b antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Atp4b antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Atp4b |
|---|---|
| Function | The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Single-pass type II membrane protein. Cell membrane {ECO:0000250|UniProtKB:P18597}; Single- pass type II membrane protein. Note=Localized in the apical canalicular membrane of parietal cells {ECO:0000250|UniProtKB:P20648} |
| Tissue Location | Stomach.. |
Citations (0)
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Application Protocols
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$ 389.00
Cat# AI12407
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