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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   TGFBR2 antibody - N-terminal region   

TGFBR2 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - TGFBR2 antibody - N-terminal region AI12490

    WB Suggested Anti-TGFBR2 Antibody Titration: 5.0μg/ml
    Positive Control: HepG2 cell lysate
    TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P37173
Other Accession NM_003242, NP_003233
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Sheep, Bovine
Predicted Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 62kDa
Additional Information
Gene ID 7048
Alias Symbol HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII
Other Names TGF-beta receptor type-2, TGFR-2,, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 100 ul of distilled water. Final anti-TGFBR2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTGFBR2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
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$ 232.00
Cat# AI12490
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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