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Ano6 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6P9J9 |
| Other Accession | NM_175344, NP_780553 |
| Reactivity | Human, Mouse, Rat, Pig, Guinea Pig |
| Predicted | Human, Mouse, Rat, Pig, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 106kDa |
| Gene ID | 105722 |
|---|---|
| Alias Symbol | 2900059G15Rik, AA407480, AW554778, F730003B03Rik, Tmem16f |
| Other Names | Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, Ano6, Tmem16f |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Ano6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Ano6 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ano6 |
|---|---|
| Function | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Shows an intracellular localization. {ECO:0000250|UniProtKB:Q4KMQ2} |
| Tissue Location | Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 389.00
Cat# AI12495
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