B4galt5 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9JMK0 |
Other Accession | NM_019835, NP_062809 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Gene ID | 56336 |
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Alias Symbol | 9430078I07Rik, AW049941, AW539721 |
Other Names | Beta-1, 4-galactosyltransferase 5, Beta-1, 4-GalTase 5, Beta4Gal-T5, b4Gal-T5, 2.4.1.-, Beta-1, 4-GalT II, UDP-Gal:beta-GlcNAc beta-1, 4-galactosyltransferase 5, UDP-galactose:beta-N-acetylglucosamine beta-1, 4-galactosyltransferase 5, B4galt5, Bgt-5 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-B4galt5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | B4galt5 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | B4galt5 {ECO:0000312|MGI:MGI:1927169} |
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Synonyms | Bgt-5 |
Function | Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:21057870, PubMed:23882130, PubMed:30114188). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (PubMed:30114188). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (PubMed:29415997). Essential for extraembryonic development during early embryogenesis (PubMed:20574042, PubMed:21057870). |
Cellular Location | Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein Golgi apparatus {ECO:0000250|UniProtKB:A0A1S6M251}. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291} |
Tissue Location | Highest levels in heart, brain, liver and kidney with lower levels in spleen, lung and testis |
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