Bace1 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P56818 |
Other Accession | NM_011792, NP_035922 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Horse, Bovine, Guinea Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 56kDa |
Gene ID | 23821 |
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Alias Symbol | C76936 |
Other Names | Beta-secretase 1, 3.4.23.46, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, Bace1, Bace |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Bace1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Bace1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Bace1 {ECO:0000312|MGI:MGI:1346542} |
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Synonyms | Bace |
Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56817}. Endosome. Late endosome. Early endosome. Cell surface. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P56817}. Membrane raft. Lysosome Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity) {ECO:0000250|UniProtKB:P56817, ECO:0000269|PubMed:25592972} |
Tissue Location | Expressed in the brain, specifically in neurons and astrocytes (at protein level). |
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