|Other Accession||NM_014674, NP_055489|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Guinea Pig, Dog|
|Alias Symbol||EDEM, KIAA0212|
|Other Names||ER degradation-enhancing alpha-mannosidase-like protein 1, EDEM1, EDEM, KIAA0212|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-EDEM1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||EDEM1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
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