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ZDHHC17 antibody - middle region

Rabbit Polyclonal Antibody

     
  • IHC - ZDHHC17 antibody - middle region AI12748
    Rabbit Anti-ZDHHC17 Antibody
    Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue Observed Staining: Cytoplasmic in vesicles and processes of pinealocytes
    Primary Antibody
    Concentration: 1:100
    Secondary Antibody: Donkey anti-Rabbit-Cy3
    Secondary Antibody
    Concentration: 1:200
    Magnification: 20X
    Exposure Time: 0.5 - 2.0 sec
    detail
  • WB - ZDHHC17 antibody - middle region AI12748

    WB Suggested Anti-ZDHHC17 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Hela cell lysate
    ZDHHC17 is supported by BioGPS gene expression data to be expressed in HeLa
    detail
  • WB - ZDHHC17 antibody - middle region AI12748

    Host: Rabbit
    Target Name: ZDHHC17
    Sample Tissue: Hela
    Antibody Dilution: 1.0μg/mlZDHHC17 is supported by BioGPS gene expression data to be expressed in HeLa
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q8IUH5
Other Accession NM_015336, NP_056151
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Mouse, Rat, Rabbit, Zebrafish, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Additional Information
Gene ID 23390
Alias Symbol HIP14, HIP3, HSPC294, HYPH, KIAA0946
Other Names Palmitoyltransferase ZDHHC17, 2.3.1.225, Huntingtin yeast partner H, Huntingtin-interacting protein 14, HIP-14, Huntingtin-interacting protein 3, HIP-3, Huntingtin-interacting protein H, Putative MAPK-activating protein PM11, Putative NF-kappa-B-activating protein 205, Zinc finger DHHC domain-containing protein 17, DHHC-17, ZDHHC17, HIP14, HIP3, HYPH, KIAA0946
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ZDHHC17 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsZDHHC17 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZDHHC17 (HGNC:18412)
Function Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:15489887, PubMed:15603740, PubMed:24705354, PubMed:27911442, PubMed:28757145). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity). May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793). May play a role in Mg(2+) transport (PubMed:18794299). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed:27911442).
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles
Tissue Location Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.
Research Areas
Citations (0)
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$ 389.00
Cat# AI12748
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