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Dhrs7 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9CXR1 |
| Other Accession | NM_025522, NP_079798 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32kDa |
| Gene ID | 66375 |
|---|---|
| Alias Symbol | 2310016E22Rik, 5730564L20Rik, AW061210, Retdsr4, Retsdr4 |
| Other Names | Dehydrogenase/reductase SDR family member 7, 1.1.-.-, Retinal short-chain dehydrogenase/reductase 4, retSDR4, Dhrs7, Retsdr4 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Dhrs7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Dhrs7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Dhrs7 {ECO:0000312|MGI:MGI:1913625} |
|---|---|
| Synonyms | Retsdr4 |
| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y394}. Note=Bound to the endoplasmic reticulum membrane, possibly through a N-terminus anchor. The main bulk of the polypeptide chain was first reported to be facing toward the lumen of the endoplasmic reticulum. However, it was later shown to be facing the cytosol. {ECO:0000250|UniProtKB:Q9Y394} |
Research Areas
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Application Protocols
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$ 389.00
Cat# AI12758
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