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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Fto antibody - N-terminal region   

Fto antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Fto antibody - N-terminal region AI12799

    WB Suggested Anti-Fto Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Mouse Brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8BGW1
Other Accession NM_011936, NP_036066
Reactivity Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Yeast, Bovine, Dog
Predicted Human, Mouse, Rat, Rabbit, Pig, Sheep, Horse, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 58kDa
Additional Information
Gene ID 26383
Alias Symbol AW743446, mKIAA1752
Other Names Alpha-ketoglutarate-dependent dioxygenase FTO, 1.14.11.-, Fat mass and obesity-associated protein, Protein fatso, Fto, Kiaa1752
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Fto antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFto antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Fto
Synonyms Kiaa1752
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Cellular Location Nucleus. Nucleus speckle
Tissue Location Ubiquitous. Detected in brain, brain cortex, hypothalamus, cerebellum, liver, pancreas, heart, kidney, white adipose tissue and skeletal muscle. Most abundant in the brain, particularly in hypothalamic nuclei governing energy balance
Research Areas
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$ 293.00
Cat# AI12799
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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