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THG1L antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NWX6 |
| Other Accession | NM_017872, NP_060342 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Chicken, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35kDa |
| Gene ID | 54974 |
|---|---|
| Alias Symbol | FLJ11601, FLJ20546, ICF45 |
| Other Names | Probable tRNA(His) guanylyltransferase, 2.7.7.79, Interphase cytoplasmic foci protein 45, tRNA-histidine guanylyltransferase, THG1L, ICF45 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-THG1L antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | THG1L antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | THG1L |
|---|---|
| Synonyms | ICF45 |
| Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223). By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223). |
| Cellular Location | Cytoplasm. Mitochondrion outer membrane |
| Tissue Location | Expressed in many tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Guo,D.,(2004)J.Biol.Chem.279(51),53498-53505ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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