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Tnik antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Tnik antibody - middle region AI12939

    WB Suggested Anti-Tnik Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Spleen
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P83510
Other Accession NM_001163008, NP_001156480
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 145kDa
Additional Information
Gene ID 665113
Alias Symbol 1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik, KIAA0551, MGC189819, MGC189859
Other Names Traf2 and NCK-interacting protein kinase, 2.7.11.1, Tnik, Kiaa0551
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Tnik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTnik antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tnik
Synonyms Kiaa0551
Function Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading (By similarity).
Cellular Location Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Research Areas
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$ 293.00
Cat# AI12939
Size:
Quantity:
(40 western blots)
Availability: 2-3 days
Bulk Size
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