|Other Accession||NM_172527, NP_766115|
|Reactivity||Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Yeast, Bovine, Guinea Pig, Dog|
|Predicted||Mouse, Rat, Zebrafish, Chicken, Guinea Pig, Dog|
|Alias Symbol||6530403O17, A730068G11Rik, MTH2|
|Other Names||Probable 8-oxo-dGTP diphosphatase NUDT15, 8-oxo-dGTPase NUDT15, 184.108.40.206, 7, 8-dihydro-8-oxoguanine-triphosphatase NUDT15, MutT homolog 2, mMTH2, Nucleoside diphosphate-linked moiety X motif 15, Nudix motif 15, Nudt15, Mth2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Nudt15 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Nudt15 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.|
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