NUDT18 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q6ZVK8 |
Other Accession | NM_024815, NP_079091 |
Reactivity | Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Rat, Rabbit, Pig, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 35kDa |
Gene ID | 79873 |
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Alias Symbol | FLJ22494 |
Other Names | 8-oxo-dGDP phosphatase NUDT18, 3.6.1.58, 2-hydroxy-dADP phosphatase, 7, 8-dihydro-8-oxoguanine phosphatase, MutT homolog 3, Nucleoside diphosphate-linked moiety X motif 18, Nudix motif 18, NUDT18, MTH3 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-NUDT18 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | NUDT18 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NUDT18 (HGNC:26194) |
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Function | Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. |
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Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Takagi Y.,et al.J. Biol. Chem. 287:21541-21549(2012).
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