|Other Accession||NM_024815, NP_079091|
|Reactivity||Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Other Names||8-oxo-dGDP phosphatase NUDT18, 18.104.22.168, 2-hydroxy-dADP phosphatase, 7, 8-dihydro-8-oxoguanine phosphatase, MutT homolog 3, Nucleoside diphosphate-linked moiety X motif 18, Nudix motif 18, NUDT18, MTH3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-NUDT18 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NUDT18 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Takagi Y.,et al.J. Biol. Chem. 287:21541-21549(2012).
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