|Other Accession||NM_152490, NP_689703|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||B3GalNAc-T2, MGC39558|
|Other Names||UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2, Beta-1, 3-GalNAc-T2, 2.4.1.-, Beta-1, 3-N-acetylgalactosaminyltransferase II, B3GALNT2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-B3GALNT2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||B3GALNT2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum|
|Tissue Location||Expressed in all tissues examined, but at highest levels in testis, adipose tissue, skeletal muscle and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
Gregory S.G.,et al.Nature 441:315-321(2006).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Hiruma T.,et al.J. Biol. Chem. 279:14087-14095(2004).
Stevens E.,et al.Am. J. Hum. Genet. 92:354-365(2013).
Yoshida-Moriguchi T.,et al.Science 341:896-899(2013).
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