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Setd5 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q5XJV7 |
| Other Accession | NM_028385, NP_082661 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 157kDa |
| Gene ID | 72895 |
|---|---|
| Alias Symbol | 2900045N06Rik, C330007C20, C85544, FLJ10707, MGC90828, mKIAA1757 |
| Other Names | SET domain-containing protein 5, Setd5, Kiaa1757 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Setd5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Setd5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Setd5 {ECO:0000303|PubMed:27864380, ECO:0000312|MGI:MGI:1920145} |
|---|---|
| Function | Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission (PubMed:30455454, PubMed:31515109). May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics (PubMed:31515109). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). The relevance of histone methyltransferase activity is however subject to discussion (PubMed:27864380, PubMed:30455454). |
| Cellular Location | Nucleus. Chromosome. Note=Localizes to active transcribed genes. |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Okazaki N.,et al.DNA Res. 10:35-48(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Villen J.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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