|Other Accession||NM_134336, NP_599163|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Neuroligin-3, Gliotactin homolog, Nlgn3|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Nlgn3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Nlgn3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia- neuron interactions in the developing peripheral nervous system.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Detected at both glutamatergic and GABAergic synapses|
|Tissue Location||Detected in brain and on hippocampus neurons, especially at excitatory synapses. Detected in retina (at protein level). Expressed in brain, spinal chord and dorsal root ganglion|
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Provided below are standard protocols that you may find useful for product applications.
Ichtchenko K.,et al.J. Biol. Chem. 271:2676-2682(1996).
Gilbert M.,et al.Glia 34:151-164(2001).
Comoletti D.,et al.J. Neurosci. 24:4889-4893(2004).
Varoqueaux F.,et al.Neuron 51:741-754(2006).
Budreck E.C.,et al.Eur. J. Neurosci. 26:1738-1748(2007).
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