Jph2 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9ET78 |
Other Accession | NM_021566, NP_067541 |
Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog |
Predicted | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 75kDa |
Gene ID | 59091 |
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Alias Symbol | 1110002E14Rik, JP-2, Jp2 |
Other Names | Junctophilin-2, JP-2, Junctophilin type 2, Jph2, Jp2 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Jph2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | Jph2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Jph2 {ECO:0000312|MGI:MGI:1891496} |
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Function | [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:10949023, PubMed:19095005, PubMed:21339484). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (PubMed:10949023, PubMed:19095005, PubMed:21339484). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (PubMed:10949023, PubMed:19095005, PubMed:21339484). Contributes to the construction of skeletal muscle triad junctions (PubMed:10949023). |
Cellular Location | [Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=The transmembrane domain is anchored in sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (PubMed:10949023). In heart cells, it predominantly associates along Z lines within myocytes (PubMed:10949023). In skeletal muscle, it is specifically localized at the junction of A and I bands (PubMed:10949023) |
Tissue Location | Abundantly expressed in skeletal muscle and heart (PubMed:10949023). Weak expression in stomach and lung (PubMed:10949023). |
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Provided below are standard protocols that you may find useful for product applications.
References
Takeshima H.,et al.Mol. Cell 6:11-22(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Yamazaki D.,et al.Pharmacol. Ther. 121:265-272(2009).
van Oort R.J.,et al.Circulation 123:979-988(2011).
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