|Other Accession||NM_021566, NP_067541|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog|
|Alias Symbol||1110002E14Rik, JP-2, Jp2|
|Other Names||Junctophilin-2, JP-2, Junctophilin type 2, Jph2, Jp2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Jph2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Jph2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.|
|Cellular Location||Cell membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes In skeletal muscle, it is specifically localized at the junction of A and I bands|
|Tissue Location||Abundantly expressed in skeletal muscle and heart. Weak expression in stomach and lung|
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Provided below are standard protocols that you may find useful for product applications.
Takeshima H.,et al.Mol. Cell 6:11-22(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Yamazaki D.,et al.Pharmacol. Ther. 121:265-272(2009).
van Oort R.J.,et al.Circulation 123:979-988(2011).
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