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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   Jph2 antibody - N-terminal region   

Jph2 antibody - N-terminal region

Rabbit Polyclonal Antibody

  • WB - Jph2 antibody - N-terminal region AI13039

    WB Suggested Anti-Jph2 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Pancreas
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9ET78
Other Accession NM_021566, NP_067541
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 75kDa
Additional Information
Gene ID 59091
Alias Symbol 1110002E14Rik, JP-2, Jp2
Other Names Junctophilin-2, JP-2, Junctophilin type 2, Jph2, Jp2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Jph2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsJph2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Jph2
Synonyms Jp2
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
Cellular Location Cell membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In heart cells, it predominantly associates along Z lines within myocytes In skeletal muscle, it is specifically localized at the junction of A and I bands
Tissue Location Abundantly expressed in skeletal muscle and heart. Weak expression in stomach and lung
Research Areas
Citations (0)

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Takeshima H.,et al.Mol. Cell 6:11-22(2000).
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Yamazaki D.,et al.Pharmacol. Ther. 121:265-272(2009).
van Oort R.J.,et al.Circulation 123:979-988(2011).

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$ 293.00
Cat# AI13039
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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