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LASS1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - LASS1 antibody - middle region AI13060

    WB Suggested Anti-LASS1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: OVCAR-3 cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P27544
Other Accession NM_021267, NP_067090
Reactivity Human, Mouse, Rat, Horse
Predicted Human, Mouse, Rat, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Additional Information
Gene ID 10715
Alias Symbol CerS1, LAG1, MGC90349, UOG1, LASS1
Other Names Ceramide synthase 1, CerS1, LAG1 longevity assurance homolog 1, Longevity assurance gene 1 protein homolog 1, Protein UOG-1, CERS1, LAG1, LASS1, UOG1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-LASS1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsLASS1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CERS1 {ECO:0000303|PubMed:17977534, ECO:0000312|HGNC:HGNC:14253}
Function Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624, PubMed:24782409). Plays a predominant role in skeletal muscle in regulating C18 ceramide and dihydroceramide levels with an impact on whole-body glucose metabolism and insulin sensitivity. Protects from diet-induced obesity by suppressing the uptake of glucose in multiple organs in a FGF21-dependent way (By similarity). Generates C18 ceramides in the brain, playing a critical role in cerebellar development and Purkinje cell function (By similarity). In response to cellular stress mediates mitophagy, a known defense mechanism against cell transformation and aging. Upon mitochondria fission, generates C18 ceramides that anchor lipidated MAP1LC3B/LC3B-II autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria (PubMed:22922758).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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References

Lee S.-J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:4250-4254(1991).
Jiang J.C.,et al.Genome Res. 8:1259-1272(1998).
Grimwood J.,et al.Nature 428:529-535(2004).
Bienvenut W.V.,et al.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).

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$ 389.00
Cat# AI13060
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