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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SIGIRR antibody - C-terminal region   

SIGIRR antibody - C-terminal region

Rabbit Polyclonal Antibody

  • IHC - SIGIRR antibody - C-terminal region AI13062
  • WB - SIGIRR antibody - C-terminal region AI13062

    WB Suggested Anti-SIGIRR Antibody Titration: 0.2-1 μg/ml
    Positive Control: Jurkat cell lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6IA17
Other Accession XP_001129013
Reactivity Human, Mouse, Rat, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Chicken, Horse, Bovine, Guinea Pig, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Additional Information
Gene ID 59307
Alias Symbol MGC110992, TIR8
Other Names Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8, SIGIRR
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-SIGIRR antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsSIGIRR antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Cellular Location Membrane; Single-pass type III membrane protein
Tissue Location Mainly expressed in epithelial tissues such as kidney, lung and gut.
Research Areas
Citations (0)

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Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
Thomassen E.,et al.Cytokine 11:389-399(1999).

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$ 293.00
Cat# AI13062
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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