|Other Accession||NM_199393, NP_955425|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rabbit, Pig, Chicken, Horse, Bovine, Dog|
|Other Names||Polypeptide N-acetylgalactosaminyltransferase 11, 220.127.116.11, Polypeptide GalNAc transferase 11, GalNAc-T11, pp-GaNTase 11, Protein-UDP acetylgalactosaminyltransferase 11, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11, Galnt11|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Galnt11 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Galnt11 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N- acetylgalactosaminyltransferases catalyze the transfer of an N- acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity).|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in kidney. Weakly expressed in other tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Schwientek T.,et al.J. Biol. Chem. 277:22623-22638(2002).
Shimoji S.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Carninci P.,et al.Science 309:1559-1563(2005).
Boskovski M.T.,et al.Nature 504:456-459(2013).
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