C20orf116 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q96HY6 |
Other Accession | NM_023935, NP_076424 |
Reactivity | Human, Rabbit, Horse, Bovine, Dog |
Predicted | Human, Rabbit, Horse, Bovine, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 35kDa |
Gene ID | 65992 |
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Alias Symbol | MGC2592, dJ1187M17.3, UFBP1, C20orf116 |
Other Names | DDRGK domain-containing protein 1, UFM1-binding and PCI domain-containing protein 1, DDRGK1 (HGNC:16110) |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C20orf116 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | C20orf116 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DDRGK1 {ECO:0000303|PubMed:20228063, ECO:0000312|HGNC:HGNC:16110} |
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Function | Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) (PubMed:32160526). In response to endoplasmic reticulum stress, promotes recruitment of the E3 UFM1-protein ligase UFL1 to the endoplasmic reticulum membrane: in turn, UFL1 mediates ufmylation of proteins such as RPN1 and RPL26/uL24, promoting reticulophagy of endoplasmic reticulum sheets (PubMed:32160526). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (PubMed:28128204, PubMed:32160526). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis or inflammatory response (By similarity). Required for TRIP4 ufmylation, thereby regulating nuclear receptors-mediated. transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). |
Cellular Location | Endoplasmic reticulum. Endoplasmic reticulum membrane. Note=Localizes to the endoplasmic reticulum membrane in response to endoplasmic reticulum stress. |
Tissue Location | Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe. |
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Provided below are standard protocols that you may find useful for product applications.
References
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Deloukas P.,et al.Nature 414:865-871(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tatsumi K.,et al.J. Biol. Chem. 285:5417-5427(2010).
Wu J.,et al.J. Biol. Chem. 285:15126-15136(2010).
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