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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   PVRIG antibody - middle region   

PVRIG antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - PVRIG antibody - middle region AI13083

    WB Suggested Anti-PVRIG Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:1562500
    Positive Control: Human brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q6DKI7
Other Accession NM_024070, NP_076975
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Additional Information
Gene ID 79037
Alias Symbol C7orf15, MGC104322, MGC138295, MGC138297, MGC2463
Other Names Transmembrane protein PVRIG, Poliovirus receptor-related immunoglobulin domain-containing protein, PVRIG, C7orf15
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-PVRIG antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsPVRIG antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PVRIG
Synonyms C7orf15
Function Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.
Research Areas
Citations (0)

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References

Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wilson M.D.,et al.Physiol. Genomics 27:201-218(2006).

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$ 293.00
Cat# AI13083
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