|Other Accession||NM_024070, NP_076975|
|Alias Symbol||C7orf15, MGC104322, MGC138295, MGC138297, MGC2463|
|Other Names||Transmembrane protein PVRIG, Poliovirus receptor-related immunoglobulin domain-containing protein, PVRIG, C7orf15|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PVRIG antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PVRIG antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.|
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Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Wilson M.D.,et al.Physiol. Genomics 27:201-218(2006).
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