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STEAP4 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q687X5 |
| Other Accession | NM_024636, NP_078912 |
| Reactivity | Human, Rabbit, Bovine |
| Predicted | Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52kDa |
| Gene ID | 79689 |
|---|---|
| Alias Symbol | DKFZp666D049, FLJ23153, STAMP2, TIARP, TNFAIP9 |
| Other Names | Metalloreductase STEAP4, 1.16.1.-, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2, Tumor necrosis factor, alpha-induced protein 9, STEAP4, STAMP2, TNFAIP9 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-STEAP4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | STEAP4 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STEAP4 |
|---|---|
| Synonyms | STAMP2 {ECO:0000303|PubMed:15897894}, TN |
| Function | Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage- independent cell proliferation (PubMed:19787193). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Korkmaz C.G.,et al.Oncogene 24:4934-4945(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ohgami R.S.,et al.Nat. Genet. 37:1264-1269(2005).
Zhang C.M.,et al.Acta Pharmacol. Sin. 29:587-592(2008).
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$ 389.00
Cat# AI13090
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