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UNC84A antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • IHC - UNC84A antibody - N-terminal region AI13105
    Sample Type : Mouse C2C12 cells
    Primary Antibody Dilution : 1:500
    Secondary Antibody : Goat anti-rabbit-Alexa Fluor 488 Secondary Antibody Dilution : 1:500 Color/Signal Descriptions : UNC84a: Green DAPI: Blue
    Gene Name : UNC84A Submitted by : Dr. David Razafsky, Washington University in Saint Louis
  • WB - UNC84A antibody - N-terminal region AI13105

    WB Suggested Anti-UNC84A Antibody Titration: 0.2-1 μg/ml
    Positive Control: Jurkat cell lysate
  • WB - UNC84A antibody - N-terminal region AI13105

    Host: Rabbit
    Target Name: UNC84A
    Sample Tissue: Human Adult Placenta
    Antibody Dilution: 1.0μg/ml
  • WB - UNC84A antibody - N-terminal region AI13105

    Host: Rabbit
    Target Name: SUN1
    Sample Tissue: Jurkat Whole Cell lysates
    Antibody Dilution: 3μg/ml
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession O94901
Other Accession NM_025154, NP_079430
Reactivity Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Additional Information
Gene ID 23353
Alias Symbol FLJ12407, KIAA0810, MGC176649, SUN1, UNC84A
Other Names SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-UNC84A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsUNC84A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUN1
Synonyms KIAA0810, UNC84A
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis.
Cellular Location Nucleus inner membrane; Single-pass type II membrane protein. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles {ECO:0000250|UniProtKB:Q9D666}
Citations (0)

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References

Nagase T.,et al.DNA Res. 5:277-286(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 424:157-164(2003).
Malone C.J.,et al.Development 126:3171-3181(1999).

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$ 293.00
Cat# AI13105
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