|Other Accession||NM_031952, NP_114158|
|Reactivity||Human, Pig, Horse, Bovine, Dog|
|Alias Symbol||FLJ35906, NYD-SP16|
|Other Names||Spermatogenesis-associated protein 9, Testis development protein NYD-SP16, SPATA9|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-SPATA9 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SPATA9 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Highly expressed in testes and pancreas. Low levels found in the heart, lungs, and brain. Very low expression detected in the placenta. No expression seen in skeletal muscle, liver, kidney, thymus, small intestine, colons, spleen, leukocytes, prostate gland, and ovary. In the adult testes, expression was about 6.44-fold higher than in the embryo testes No expression in testes of patients with Sertoli-cell-only syndrome. In patients with arrest at spermatogonium and primary spermatocyte stages, no expression was detected. In patients with arrest at the spermatid stage, expression level was weak or absent. Variable expression was seen in patients with spermatogenic arrest. EMBL; AY027526; AAK16746.1; -; mRNA EMBL; AK093225; BAC04101.1; -; mRNA EMBL; AK292338; BAF85027.1; -; mRNA EMBL; BC032832; AAH32832.1; -; mRNA EMBL; BC047333; AAH47333.1; -; mRNA CCDS; CCDS4076.1; -. [Q9BWV2-1] RefSeq; NP_114158.2; NM_031952.3. [Q9BWV2-1] RefSeq; XP_011541968.1; XM_011543666.1. [Q9BWV2-2] RefSeq; XP_016865437.1; XM_017009948.1. [Q9BWV2-1] UniGene; Hs.50499; - ProteinModelPortal; Q9BWV2; - SMR; Q9BWV2; - STRING; 9606.ENSP00000274432; - PhosphoSitePlus; Q9BWV2; - BioMuta; SPATA9; - DMDM; 126253804; - PaxDb; Q9BWV2; - PeptideAtlas; Q9BWV2; - PRIDE; Q9BWV2; - DNASU; 83890; - Ensembl; ENST00000274432; ENSP00000274432; ENSG00000145757. [Q9BWV2-1] Ensembl; ENST00000316087; ENSP00000325491; ENSG00000145757. [Q9BWV2-1] Ensembl; ENST00000477715; ENSP00000427257; ENSG00000145757. [Q9BWV2-2] Ensembl; ENST00000489917; ENSP00000420883; ENSG00000145757. [Q9BWV2-3] GeneID; 83890; - KEGG; hsa:83890; - UCSC; uc003kli.2; human. [Q9BWV2-1] CTD; 83890; - DisGeNET; 83890; - GeneCards; SPATA9; - HGNC; HGNC:22988; SPATA9 HPA; HPA010848; - MIM; 608039; gene neXtProt; NX_Q9BWV2; - OpenTargets; ENSG00000145757; - PharmGKB; PA134900368; - eggNOG; ENOG410IN5C; Eukaryota eggNOG; ENOG4111D9E; LUCA GeneTree; ENSGT00390000014160; - HOGENOM; HOG000154372; - HOVERGEN; HBG093978; - InParanoid; Q9BWV2; - OMA; QKAIMDL; - OrthoDB; EOG091G0NXP; - PhylomeDB; Q9BWV2; - TreeFam; TF338769; - BioCyc; ZFISH:ENSG00000145757-MONOMER; - GenomeRNAi; 83890; - PRO; PR:Q9BWV2; - Proteomes; UP000005640; Chromosome 5 Bgee; ENSG00000145757; - CleanEx; HS_SPATA9; - ExpressionAtlas; Q9BWV2; baseline and differential Genevisible; Q9BWV2; HS GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW InterPro; IPR031659; SPATA9 Pfam; PF15824; SPATA9; 1 2: Evidence at transcript level; Alternative splicing; Complete proteome; Developmental protein; Differentiation; Membrane; Polymorphism; Reference proteome; Spermatogenesis; Transmembrane; Transmembrane helix CHAIN 1 254 Spermatogenesis-associated protein 9 /FTId=PRO_0000278446 TRANSMEM 143 165 Helical. VAR_SEQ 51 126 Missing (in isoform 2) /FTId=VSP_023282 VAR_SEQ 127 135 VRKGSLFEI -> EKKMGLQLS (in isoform 3) /FTId=VSP_023283 VAR_SEQ 136 254 Missing (in isoform 3) /FTId=VSP_023284 VARIANT 209 209 K -> E (in dbSNP:rs34297786) /FTId=VAR_051375 CONFLICT 24 24 I -> V (in Ref. 2; BAC04101) CONFLICT 98 98 A -> T (in Ref. 1; AAK16746) CONFLICT 102 102 L -> S (in Ref. 2; BAF85027) SEQUENCE 254 AA; 28740 MW; 045740C381DDFB7D CRC64; MPIKPVGWIC GQVLKNFSGR IEGIQKAIMD LVDEFKDEFP TILRLSQSNQ KREPAQKTSK IRMAIALAKI NRATLIRGLN SISRSSKSVA KLLHPQLACR LLELRDISGR LLREVNAPRQ PLYNIQVRKG SLFEIISFPA KTALTSIIYA SYAALIYLAV CVNAVLKKVK NIFQEEESIR QNREESENCR KAFSEPVLSE PMFAEGEIKA KPYRSLPEKP DISDYPKLLA NKQSNNIQVL HSVFDQSAEM NEQI|
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