ZBED1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O96006 |
Other Accession | NM_004729, NP_004720 |
Reactivity | Human, Rabbit, Horse, Yeast, Bovine |
Predicted | Human, Rabbit, Horse, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 78kDa |
Gene ID | 9189 |
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Alias Symbol | ALTE, DREF, KIAA0785, TRAMP, hDREF |
Other Names | Zinc finger BED domain-containing protein 1, Putative Ac-like transposable element, dREF homolog, ZBED1, ALTE, DREF, KIAA0785, TRAMP |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ZBED1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ZBED1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZBED1 |
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Function | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'- TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). |
Cellular Location | Nucleus, PML body. Nucleus. Note=In granular structures |
Tissue Location | Ubiquitously expressed at low levels (PubMed:9887332). Expression is highest in skeletal muscle, heart, spleen and placenta (PubMed:9887332). |
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Provided below are standard protocols that you may find useful for product applications.
References
Esposito T.,et al.Hum. Mol. Genet. 8:61-67(1999).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Ross M.T.,et al.Nature 434:325-337(2005).
Ohshima N.,et al.J. Biol. Chem. 278:22928-22938(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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