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ZBED1 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • WB - ZBED1 antibody - C-terminal region AI13181

    WB Suggested Anti-ZBED1 Antibody Titration: 0.2-1 μg/ml
    ELISA Titer: 1:12500
    Positive Control: Jurkat cell lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O96006
Other Accession NM_004729, NP_004720
Reactivity Human, Rabbit, Horse, Yeast, Bovine
Predicted Human, Rabbit, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Additional Information
Gene ID 9189
Alias Symbol ALTE, DREF, KIAA0785, TRAMP, hDREF
Other Names Zinc finger BED domain-containing protein 1, Putative Ac-like transposable element, dREF homolog, ZBED1, ALTE, DREF, KIAA0785, TRAMP
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ZBED1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsZBED1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZBED1
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'- TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
Cellular Location Nucleus, PML body. Nucleus. Note=In granular structures
Tissue Location Ubiquitously expressed at low levels (PubMed:9887332). Expression is highest in skeletal muscle, heart, spleen and placenta (PubMed:9887332).
Citations (0)
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References

Esposito T.,et al.Hum. Mol. Genet. 8:61-67(1999).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Ross M.T.,et al.Nature 434:325-337(2005).
Ohshima N.,et al.J. Biol. Chem. 278:22928-22938(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).

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$ 389.00
Cat# AI13181
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