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Mbtd1 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Mbtd1 antibody - middle region AI13197

    WB Suggested Anti-Mbtd1 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Pancreas
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q6P5G3
Other Accession NM_134012, NP_598773
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rabbit, Pig, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 71kDa
Additional Information
Gene ID 103537
Alias Symbol AA408199, AI194990, hemp
Other Names MBT domain-containing protein 1, Mbtd1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Mbtd1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsMbtd1 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mbtd1 {ECO:0000312|MGI:MGI:2143977}
Function Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q05BQ5}. Chromosome {ECO:0000250|UniProtKB:Q05BQ5}
Citations (0)
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References

Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Park J.,et al.Mol. Cell 50:919-930(2013).

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$ 389.00
Cat# AI13197
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