|Other Accession||NM_175175, NP_780384|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig|
|Predicted||Mouse, Rat, Chicken, Bovine, Dog|
|Alias Symbol||1110070J07Rik, AA673237, ZFYVE18|
|Other Names||Pleckstrin homology domain-containing family F member 2, PH domain-containing family F member 2, Plekhf2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Plekhf2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Plekhf2 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF- induced apoptosis.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein. Endoplasmic reticulum. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots. May translocate to the endoplasmic reticulum in the early phase of apoptosis.|
|Tissue Location||Expressed in brain, stomach and thymus, as well as in kidney, spleen, and skeletal muscle. Also expressed in peripheral blood mononuclear cells and dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
Carninci P.,et al.Science 309:1559-1563(2005).
Li C.,et al.J. Mol. Med. 86:471-484(2008).
Trost M.,et al.Immunity 30:143-154(2009).
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