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Tcf23 antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - Tcf23 antibody - middle region AI13235

    WB Suggested Anti-Tcf23 Antibody Titration: 1.0 μg/ml
    Positive Control: Mouse Spleen
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9JLR5
Other Accession NM_053085, NP_444315
Reactivity Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog
Predicted Human, Mouse, Rat, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 23kDa
Additional Information
Gene ID 69852
Alias Symbol 2010002O16Rik, Out, bHLHa24
Other Names Transcription factor 23, TCF-23, Basic helix-loop-helix transcription factor OUT, Ovary, uterus and testis protein, Tcf23, Out
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-Tcf23 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsTcf23 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tcf23
Synonyms Out
Function Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis.
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:10652346}
Tissue Location Highly expressed in the uterus (predominantly in myometrium), ovary, and testis. Expression in the uterus is higher in the diestrus phase than in the estrus phase and reaches a maximum at 7.5 dpc. Expression declines towards the time of delivery and returns to the non-pregnant level 4 days after delivery. Low expression seen in lung, heart, intestine, and spleen.
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References

Narumi O.,et al.J. Biol. Chem. 275:3510-3521(2000).
Carninci P.,et al.Science 309:1559-1563(2005).

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$ 389.00
Cat# AI13235
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