|Other Accession||NM_000944, NP_000935|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Dog|
|Alias Symbol||CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B|
|Other Names||Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, 188.8.131.52, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, Ppp3ca, Calna|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-PPP3CA antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PPP3CA antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (By similarity).|
|Cellular Location||Cell membrane. Cell membrane, sarcolemma. Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Ito A.,et al.Biochem. Biophys. Res. Commun. 163:1492-1497(1989).
Perrino B.A.,et al.J. Biol. Chem. 267:15965-15969(1992).
Chang C.,et al.Biochem. J. 288:801-805(1992).
Lubec G.,et al.Submitted (JUL-2007) to UniProtKB.
Wadzinski B.E.,et al.J. Biol. Chem. 265:21504-21508(1990).
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