|Other Accession||NM_020782, NP_065833|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Alias Symbol||KIAA1340, MGC131714, Ctb9, KLHDC5|
|Other Names||Kelch-like protein 42, Cullin-3-binding protein 9, Ctb9, Kelch domain-containing protein 5, KLHL42, KIAA1340, KLHDC5|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-KLHDC5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||KLHDC5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis|
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Provided below are standard protocols that you may find useful for product applications.
Scherer S.E.,et al.Nature 440:346-351(2006).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Matsuoka S.,et al.Science 316:1160-1166(2007).
Cummings C.M.,et al.J. Biol. Chem. 284:11663-11675(2009).
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