|Other Accession||NM_001001655, NP_001001655|
|Reactivity||Human, Mouse, Rat, Rabbit, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Pig, Dog|
|Alias Symbol||ABH2, MGC90512, hABH2|
|Other Names||Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, 188.8.131.52, Alkylated DNA repair protein alkB homolog 2, DNA oxidative demethylase ALKBH2, Oxy DC1, ALKBH2, ABH2|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ALKBH2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ALKBH2 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.|
|Cellular Location||Nucleus. Note=Detected in replication foci during S-phase|
|Tissue Location||Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.|
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Provided below are standard protocols that you may find useful for product applications.
Lin Y.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Tsujikawa K.,et al.J. Cell. Mol. Med. 11:1105-1116(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).
Duncan T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:16660-16665(2002).
Aas P.A.,et al.Nature 421:859-863(2003).
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