|Other Accession||NM_024130, NP_077044|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Other Names||Dynactin subunit 1, 150 kDa dynein-associated polypeptide, DAP-150, DP-150, p150-glued, Dctn1|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Dctn1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Dctn1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.|
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Provided below are standard protocols that you may find useful for product applications.
Holzbaur E.L.F.,et al.Nature 351:579-583(1991).
Holzbaur E.L.F.,et al.Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases.
Yan S.,et al.J. Mol. Biol. 425:4249-4266(2013).
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