|Other Accession||NM_027946, NP_082222|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog|
|Predicted||Human, Mouse, Rat, Pig, Chicken, Horse, Bovine, Guinea Pig|
|Alias Symbol||1700012F10Rik, 2610037L01Rik, C86529, HAN11, Wdr68|
|Other Names||DDB1- and CUL4-associated factor 7, WD repeat-containing protein 68, WD repeat-containing protein An11 homolog, Dcaf7, Han11, Wdr68|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Dcaf7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Dcaf7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm|
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Carninci P.,et al.Science 309:1559-1563(2005).
Morita K.,et al.J. Dermatol. Sci. 44:11-20(2006).
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