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Slu7 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8BHJ9 |
| Other Accession | NM_148673, NP_683514 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64kDa |
| Gene ID | 193116 |
|---|---|
| Alias Symbol | AU018913, D11Ertd730e, D3Bwg0878e, MGC31026, RP23-26M1.8 |
| Other Names | Pre-mRNA-splicing factor SLU7, Slu7, D11Ertd730e |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Slu7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Slu7 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Slu7 |
|---|---|
| Synonyms | D11Ertd730e |
| Function | Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:O95391}. Nucleus speckle {ECO:0000250|UniProtKB:O95391}. Cytoplasm {ECO:0000250|UniProtKB:O95391}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules {ECO:0000250|UniProtKB:O95391} |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Carninci P.,et al.Science 309:1559-1563(2005).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
Trost M.,et al.Immunity 30:143-154(2009).
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$ 389.00
Cat# AI13382
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