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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VPS26B antibody - C-terminal region   

VPS26B antibody - C-terminal region

Rabbit Polyclonal Antibody

  • WB - VPS26B antibody - C-terminal region AI13415

    WB Suggested Anti-VPS26B Antibody Titration: 0.2-1 μg/ml
    Positive Control: Human brain
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q4G0F5
Other Accession NM_052875, NP_443107
Reactivity Human, Mouse, Rat, Rabbit, Pig, Goat, Horse, Yeast, Bovine, Guinea Pig, Dog
Predicted Human, Rat, Rabbit, Pig, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Additional Information
Gene ID 112936
Alias Symbol MGC10485, Pep8b
Other Names Vacuolar protein sorting-associated protein 26B, Vesicle protein sorting 26B, VPS26B
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-VPS26B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsVPS26B antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VPS26B
Function Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}. Early endosome {ECO:0000250|UniProtKB:Q8C0E2}. Late endosome {ECO:0000250|UniProtKB:Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity) {ECO:0000250|UniProtKB:Q8C0E2}
Research Areas
Citations (0)

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Kim N.-S.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).

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$ 293.00
Cat# AI13415
(40 western blots)
Availability: 2-3 days
Bulk Size
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