|Other Accession||NM_009895, NP_034025|
|Reactivity||Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Dog|
|Predicted||Human, Mouse, Rat, Rabbit, Pig, Chicken, Bovine, Dog|
|Alias Symbol||AI385595, CIS1, Cis, F17, F23|
|Other Names||Cytokine-inducible SH2-containing protein, CIS, CIS-1, Suppressor of cytokine signaling, SOCS, Cish, Cis|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-Cish antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Cish antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).|
|Tissue Location||Expressed in kidney, lung and liver. Detected to a lower extent in stomach and heart|
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Provided below are standard protocols that you may find useful for product applications.
Yoshimura A.,et al.EMBO J. 14:2816-2826(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Matsumoto A.,et al.Blood 89:3148-3154(1997).
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