|Other Accession||NM_152345, NP_689558|
|Reactivity||Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog|
|Predicted||Human, Rat, Pig, Bovine, Guinea Pig|
|Alias Symbol||FLJ20418, FLJ25555|
|Other Names||Ankyrin repeat domain-containing protein 13B, ANKRD13B|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 ul of distilled water. Final anti-ANKRD13B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ANKRD13B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.|
|Cellular Location||Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane|
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Provided below are standard protocols that you may find useful for product applications.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Tanno H.,et al.Mol. Biol. Cell 23:1343-1353(2012).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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