ANKRD13B antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q86YJ7 |
Other Accession | NM_152345, NP_689558 |
Reactivity | Human, Mouse, Rat, Pig, Bovine, Guinea Pig, Dog |
Predicted | Human, Rat, Pig, Bovine, Guinea Pig |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 70kDa |
Gene ID | 124930 |
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Alias Symbol | FLJ20418, FLJ25555 |
Other Names | Ankyrin repeat domain-containing protein 13B, ANKRD13B |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ANKRD13B antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ANKRD13B antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANKRD13B |
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Function | Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. |
Cellular Location | Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane |
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Provided below are standard protocols that you may find useful for product applications.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Tanno H.,et al.Mol. Biol. Cell 23:1343-1353(2012).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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