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9030625A04Rik antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8BZT9 |
| Other Accession | NM_172488, NP_766076 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47kDa |
| Gene ID | 210808 |
|---|---|
| Alias Symbol | Lacc1, 9030625A04Rik |
| Other Names | Laccase domain-containing protein 1, Lacc1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-9030625A04Rik antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | 9030625A04Rik antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Lacc1 {ECO:0000312|MGI:MGI:2445077} |
|---|---|
| Function | Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1- phosphate and the respective free bases, adenine, guanine and hypoxanthine (By similarity). Also catalyzes the phosphorolysis of S- methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (By similarity). Also has adenosine deaminase activity (By similarity). Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:27478939, PubMed:31978345). Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic- mitochondrial redox interface (PubMed:31978345). The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345). Participates in pattern recognition receptor-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (By similarity). Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (By similarity). Does not show laccase activity (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IV20}. Peroxisome {ECO:0000250|UniProtKB:Q8IV20}. Note=Upon stimulation of the pattern- recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8IV20} |
| Tissue Location | Predominantly expressed in myeloid cells (PubMed:30510070). Highly expressed in primary macrophages and dendritic cells sorted from the peritoneum or spleen, respectively (at protein level) (PubMed:30510070). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Carninci P.,et al.Science 309:1559-1563(2005).
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$ 389.00
Cat# AI13514
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